When starting out with nothing, I find it's not even worth trying to avoid zombies. I just run like a madman around the closest major city and start by checking every large building. If you have zombies chasing you the church is a good spot to go first. It often has a rifle or sidearm and if it doesn't, you can sit at the back, let all the zombies trickle towards you, then run around them and out the door. By the time they turn and get back outside, you should be long gone. Voila no more aggro. Same idea goes for large buildings with multiple exits. It's not the safest approach but I'd rather spend 5 minutes gambling and dying than crawling on my stomach naked and defenseless for 20 mins, only to get shot or hacked to death anyway. Or eaten for that matter. Whatever method you choose, once you have meds and at least a decent gun, start planning your departure. I generally plan my run so that whatever I do, my last buildings are at the outskirts of town. From that point you just gotta bolt the hell out of there. Again I prefer to run while bobbing and weaving to avoid possible murdering asshole fire rather than crawling around. Concerning assholes, I should also mention that you don't ever check the northeastern elektro firehouse or ever exit from that part of town. The nearby hill overlooking the city almost always has at least 1 guy sitting there just to shit on your day. Now assuming you escape the player threat, even if you have 20 zombies chasing you just don't stop and don't panic. This is where it pays to know the route for your mad dash ahead of time. There are 2 ways to lose zombies besides killing them with a weapon. 1.You can lead the trail to any steep incline, when I say steep I mean steep enough that your character has to carefully walk down rather than run. Zombies cannot do this and will instead run off the edge like Wile E. Coyote and usually drop to their deaths. Pick off the rest with your weapon or run in big circles and repeat until they're all dead. If this isn't an option then there's #2. Run into the forest and run through every bush and cluster of trees you can find. Never backtrack close enough that the zombies you lost can see you again. Slowly but surely you will lose them until there's a small enough amount that you can just shoot them with whatever you have.